Covishield was developed by AstraZeneca and was produced by the Serum Institute of India.In India, it was one of the widely administered COVID vaccine.
What did AstraZeneca say about the vaccine side effect?
Currently, AstraZeneca is facing a class action lawsuit in the UK due to claims that its vaccine caused deaths. 51 cases have been filed against AstraZeneca.
In one of the court papers, AstraZeneca has admitted that Covishield can “in very rare cases, cause TTS”. TTS stands for Thrombosis with Thrombocytopenia Syndrome.
What is TTS?
Thrombosis with thrombocytopenia syndrome (TTS) is a rare but serious condition characterized by blood clot formation (thrombosis) coupled with low platelet counts (thrombocytopenia).
TTS typically manifests with symptoms such as severe headaches, abdominal pain, leg swelling, shortness of breath, and neurological deficits. Diagnosis involves blood tests to assess platelet levels and imaging studies to detect blood clots.
Treatment for TTS involves a multidisciplinary approach, including hospitalization, anticoagulation therapy to prevent further clotting, and supportive care. Intravenous immunoglobulin (IVIG) and plasma exchange may also be utilized to stabilize platelet levels and manage immune-mediated reactions.
Healthcare providers closely monitor patients with TTS due to the potential for severe complications, including organ damage and death. Prompt recognition and management are essential for improving outcomes in individuals affected by this rare but critical syndrome.
“TTS is thrombosis with thrombocytopenia syndrome, which is basically clot in blood vessels of the brain or elsewhere, along with a low platelet count. It is known to occur in very rare instances following certain types of vaccines and also from other causes. According to the WHO, adenovirus vector vaccines in particular have been rarely associated with this condition,” Medical expert Dr Rajeev Jayadevan told ANI. “Although COVID vaccines have prevented numerous deaths, reports of these extremely rare but potentially serious immune mediated events have also been published in reputed journals,” Dr Jayadevan added.
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In 2023, the World Health Organisation (WHO) said in its report that TTS emerged as a new adverse event following immunisation in individuals vaccinated with COVID-19 non-replicant adenovirus vector-based vaccines. This refers to the AstraZeneca COVID-19 ChAdOx-1 vaccine and the Johnson & Johnson (J&J) Janssen COVID-19 Ad26.COV2-S vaccines.
“TTS is a serious and life-threatening adverse event. WHO has issued this interim emergency guidance to increase awareness about TTS in the context of COVID-19 vaccination and help healthcare providers in the assessment and management of potential TTS cases,” the 2023 statement by WHO read.
(With inputs from ANI)