Atalanta look to Gianluca Scamacca and Charles De Ketelaere, while Roma use Tommaso Baldanzi with Romelu Lukaku in this showdown for fifth place.
It kicks off at the Gewiss Stadium in Bergamo at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens from today’s five Serie A games on the LIVEBLOG.
These two teams are locked together in joint fifth place on 60 points, but La Dea have a game in hand with Fiorentina that won’t be played until June 2, after the season has effectively ended.
Both were involved in the Europa League semi-finals this week, Atalanta going through to face Bayer Leverkusen, while Gian Piero Gasperini’s men will also take on Juventus in the Coppa Italia Final on Wednesday May 15.
Sead Kolasinac, Emil Holm and Rafael Toloi are out injured, but there’s no need to rest Scamacca because he is suspended against Juve.
He is supported by De Ketelaere, Teun Koopmeiners and Mario Pasalic for a very attack-minded formation.
Roma have bigger problems to deal with, as confidence is low following two points from three Serie A rounds and the Europa League exit to Bayer Leverkusen.
Paulo Dybala is not even in the squad due to a muscular issue, with Leonardo Spinazzola also out of action.
Baldanzi therefore partners Lukaku upfront, with Stephan El Shaarawy completing the trident attack.
If Roma fail to win today, then Bologna will mathematically be qualified for the Champions League.
Atalanta vs. Roma line-ups
Atalanta: Carnesecchi; De Roon, Hien, Djimsiti; Hateboer, Koopmeiners, Ederson, Ruggeri; Pasalic; De Ketelaere, Scamacca
Roma: Svilar; Kristensen, Mancini, Ndicka, Angelino; Cristante, Paredes, Pellegrini; Baldanzi, Lukaku, El Shaarawy
29
19
33
4
22
58′ 13
88′ 8
75′ 15
7
17
58′ 90
58′ 99
5
23
43
86′ 4
86′ 16
46′ 7
46′ 90
92
1
31
2
20
25
45
43
53
77
58′ 11
58′ 10
58′ 42
75′ 59
88′ 6
1
2
63
59
22
19
14
61
3
9
46′ 52
46′ 17
86′ 67
86′